A Breakdown of Cortical Homeostasis in Depression: A Focus on the Anterior Cingulate

Grant number: 1105332 | Funding period: 2016 - 2018

Completed

Abstract

Major depressive disorders affect 20% of the Australian population. Some symptoms of major depressive disorders arise because of a dysfunction of the human brain, particularly the cortex. Our studies show there are biochemical changes in the anterior cingulate cortex in people with mood disorders. We will now extend our studies to show there is a breakdown in the balance between neurotransmitter and neuroinflammation pathways in the anterior cingulate cortex in major depressive disorders.

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University of Melbourne Researchers

Brian Dean Florey Department of Neuroscience and Mental Health

Daniel Hoyer